AVP resistance can be inherited (passed on from the parents to a child) or acquired (develop in later life).

Inherited AVP resistance is caused by a genetic mutation or ‘spelling mistake’ in the genes that the body uses to make the tubules.

AVP resistance can also develop as a result of a reaction to some medications including lithium (a psychiatric medication).

Both types of AVP resistance affect the kidneys’ tubules and cause them not to work as well as they should do.

The tubules help to balance the amounts of water, salts and minerals (electrolytes) in the body. They control how much of these substances stay in your child’s blood to keep their body healthy and how much is lost in their urine (wee).

Electrolytes help to keep your child’s muscles and heart working properly, keep their bones strong and help with their brain function.

When the tubules don’t work as they should do, the balance of water and electrolytes in the body is affected. Your child may lose too much water and electrolytes in their urine or keep more than they need. Both types of imbalances can affect your child’s health.

In AVP resistance your child’s kidneys don’t balance water as well as they should do, so too much water is lost in their urine. This can make your child feel thirsty all the time and also need to pass urine a lot.

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